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According to the International Guidelines for the management of urticaria and angioedema non-sedating, second generation antihistamines (NSAHs) are recommended for the treatment of CU [].

Nevertheless, a considerable proportion of patients do not respond sufficiently to NSAHs.

Antihistamines are a class of agents that block histamine release from histamine-1 receptors and are used to treat the symptoms of an allergic reaction, such as edema (swelling), itch, inflammation (redness), sneezing, or a runny nose or watery eyes.

Antihistamines can be further divided into those unlikely to cause drowsiness (non-sedating antihistamines) or those likely to cause drowsiness (sedating antihistamines).

Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Clinical studies sponsored by the manufacturer have shown that bilastine 20 mg once daily is as efficacious as other nonsedating antihistamines in allergic rhinoconjunctivitis and chronic urticaria in individuals from 12 and 18 years of age, respectively.

Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms.

Your doctor can guide you to the right antihistamine for you.

In the fasting state bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice.

Therefore, it is recommended that bilastine is taken at least one hour before and no sooner than two hours after a meal.

Histamine, acting on H-antihistamines help against these effects, they work only if taken before contact with the allergen.

In severe allergies, such as anaphylaxis or angioedema, these effects may be of life-threatening severity.

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